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Tunicamycin (home):

7: J Comp Pathol 2001 Nov;125(4):318-21

Effect of tunicamycin on hepatocytes in vitro.

Finnie JW.

Veterinary Services Division, Institute of Medical and Veterinary Science, 101 Blacks Road, Gilles Plains, South Australia, 5086, Australia.

Cultured rat hepatocytes exposed to tunicamycin, a substance biologically indistinguishable from the corynetoxin responsible for a toxic hepatocerebral disorder in Australian ruminant livestock, had degenerative changes characterized by marked cytoplasmic lipid accumulation and dilatation of cisternae of rough endoplasmic reticulum or necrosis. The findings, which resemble those found previously in vivo after tunicamycin administration, suggest that, after gaining ready access to liver parenchyma via leaky hepatic sinusoids, tunicamycin directly damages the hepatocytes. Copyright Harcourt Publishers Ltd.

PMID: 11798249

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A23187	Actinomycin	Aflatoxin	Anisomycin	Aphidicolin	Ascomycin
Bleomycin	Brefeldin	Cerulenin	Chromomycin	Geldanamycin	Cyclopiazonic acid
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KT5823	Mitomycin	Nigericin	Ochratoxin	Oligomycin	Mycophenolic acid
Paclitaxel	Patulin	Paxilline	Penitrem	Puromycin	Penicillic acid
Radicicol	Rapamycin	Staurosporine	Sterigmatocystin	Thapsigargin	Tunicamycin
Verruculogen	Wortmannin